Desensitization has been attempted following carbamazepine skin rash (Table 2). Because of a risk of a severe reaction, desensitization should only be undertaken in selected cases, where there are no other satisfactory alternatives. Five patients with previous severe skin reactions to carbamazepine were desensitized starting with a dose of 2.5mg/day of carba-mazepineplusan antihistamine. The dose was doubled every three days. If the rash reappeared during the desensitization, the dose was decreased to its previous level for six days before being increased again . It should be noted that concomitant antihistamine use during any desensitization protocol is generally not recommended because symptoms (eg, urticaria) may be masked. buy ampicillin

SUMMARY

A wide range of adverse effects are reported in patients who receive anticonvulsants. Both acute and chronic toxicities must be considered because many patients are on thesemedicationsfor extended periods of time. Postmarketing surveillance of the newer anticonvulsants is vital to monitor for potentially rare idiosyncratic reactions or chronic toxicities.

TABLE 2 Desensitization for management of carbamazepine/oxcarbazepine reactions