In addition to the hepatotoxicity that is seen in combination with a fever and a drug eruption (ie, anticonvulsant HSR) , there have been reports of isolated hepatic injury. Carbamazepine has been associated with granulomatous hepatitis and severe hepatic necrosis. Acute he-patotoxicity and central nervous system manifestations (eg, coma, lethargy, seizures) developed in a two and a half-year-old child after receiving excessively high doses of carba-mazepine on two occasions. Cholestatic jaundice developed in a 64-year-old woman who had received phenytoin for more than 40 years. Discontinuation of the phenytoin resulted in resolution of hepatic abnormalities, which recurred on rechallenge. Phenytoin-induced chronic hepatitis, which was verified by drug withdrawal and rechallenge, has also been reported. You will always be glad to find Generic Tavist and enjoy your online shopping.

Gastrointestinal disturbances

Minor gastrointestinal disturbances have been reported with most anticonvulsants . Nausea and vomiting can be caused by a local effect on the stomach, or may be due to a brainstem effect. Valproic acid produces a local effect on the stomach, leading to digestive complaints in up to 25% of patients . However, the availability of divalproex sodium has reduced the incidence of nausea and vomiting. In addition, taking the medication with meals may help to lessen the incidence of digestive complaints. In contrast, because of car-bamazepine’s effect on the brainstem, taking the drug with meals may not help to alleviate symptoms of nausea and vomiting. However, giving smaller doses more frequently or using a delayed-absorption formulation may reduce the incidence of this problem.