Neurotoxicity is the most common adverse effect associated with the benzodiazepines. Clobazam, a 1,5-benzodiazepine, is associated with less neurotoxicity than the 1,4-benzodiazepines (eg, nitrazepam or clonazepam) . In a study of 115 children, patients who discontinued a 1,4 benzodiazepine and who were started on clobazam showed a significant improvement in alertness. Nonetheless, one trial found that adverse effects were reported by 32% of patients on clobazam, leading to discontinuation in 9%.

Anticonvulsant encephalopathy is defined as a reversible syndrome that includes progressive mental deterioration, brainstem and cerebellar signs, electroencephalogram changes and an increase in seizure frequency. These disturbances have been described during treatment with phenytoin, carbamazepine and valproate. Find best deals online – buy allegra online can be available every time you visit.

Behavioural disturbances are reported in 20% to 30% of children with epilepsy and are often unrelated to the anticonvulsant regimen. These disturbances may result from the effect of the anticonvulsant on cerebral function or occur as a secondary reaction to the illness. Studies have shown that many children with epilepsy behave differently from healthy controls before initiating medication. Overall, behavioural disturbances are seen more frequently in children with absence and partial seizures . In a large study of 392 children receiving long term anticonvulsant therapy, behavioural effects were most commonly reported in children treated with phenobarbital and less commonly in those treated with primidone, phenytoin or valproic acid.