NEUROLOGICAL DISTURBANCES(4)

Psychiatric disturbances, including aggression and psychosis, have been reported in patients treated with vigabatrin. Psychotic symptoms may be more common in patients who experience higher levels of seizure control, who receive higher doses and who have a history of psychiatric illness. Rebound seizures and psychiatric symptoms have also been reported after abrupt discontinuation of vigabatrin . It is recommended that a low starting dosage and a slow dosage escalation be used to minimize the behavioural toxicity of this anticonvulsant . Changes in mood and affect have also been reported in conjunction with gabapentin .

A paradoxical reaction that has been linked to the barbiturates is excitation; this primarily involves physical restlessness and hyperactivity rather than true mania. Excitation is most commonly seen in children, although it has also been observed in the elderly. It has been observed to occur at serum levels too low to be associated with anticonvulsant efficacy . Insomnia has been reported with phenobarbital, pheny-toin, valproic acid, ethosuximide and vigabatrin . Carba-mazepine can cause agitation, restlessness, irritability and/or insomnia, especially in new patients . You will always find Buy Claritin online, shopping online with pleasure every time.

Cerebellar degeneration in patients receiving chronic anticonvulsant therapy has been observed . Five patients have been reported to develop irreversible ataxia and computed tomographic findings of cerebellar atrophy with chronic phenytoin therapy . All had elevated serum levels of phenytoin for varying periods of months to years, and all had received polytherapy.