AIDS-Related Bronchogenic Carcinoma. Fact or Fiction?

AIDS-Related Bronchogenic Carcinoma.Fact or Fiction?Multiple investigators have demonstrated an increased frequency of malignant neoplasms in the HIV-AIDS patient population. Kaposi’s sarcoma and malignant lymphoma are the two most widely recognized and documented associated neoplasms. The association of other non-AIDS-defining neoplasms has been regarded as somewhat more controversial. The association of primary lung carcinoma is one of these controversies. Several case reviews and retrospective analyses have raised the possibility of an increased frequency of primary lung carcinoma in this patient population. Analyses and results have often been conflicting or inconclusive. To our knowledge, no conclusive epidemiologic data have yet linked these two diseases.
Through the concerted efforts of the Texas Department of Health’s Bureau of HIV and STD (sexually transmitted diseases) Prevention and Cancer Registry Division, we conducted a population-based study of the incidence of lung neoplasms in an HIV-AIDS cohort. We present the results of our study, a review of other investigators’ work in this area, and address a potentially even greater public health problem in this population than previously realized.
Materials and Methods
A cohort of Texas residents diagnosed as having HIV-AIDS between 1990 and 1995 was identified through the AIDS surveillance program of the Bureau of HIV and STD Control, Texas Department of Health. Using a combination of active collection, collaboration with health-care workers, and ancillary data systems, this program collects demographic, mode of transmission, and clinical data for HIV-AIDS cases reported among Texas residents. To determine lung cancer incidence in this cohort, the HIV-AIDS file was confidentially matched against the cancer database of the Cancer Registry Division (CRD), also of the Texas Department of Health. The CRD maintains a comprehensive population-based cancer registry that collects demographic and diagnostic information on incident cancers in the state of Texas. This database also includes records based on death certificates in which cancer is listed as the underlying cause of death. Smoking status is not a required reportable variable for either the HIV-AIDS or the CRD database and therefore, is not consistently available.

Category: Bronchogenic Carcinoma

Tags: acquired immunodeficiency syndrome, cohort; epidemiology, human immunodeficiency virus, neoplasm, primary lung carcinoma