Cardiac contractile function and inotropic responsiveness to calcium in newborn rats from diabetic mothers (part 1)

from diabetic mothers (part 1)

We have previously shown that the cardiac contractile function and its regulation at the level of Ca2+ transport (inotropic response to Ca2+, verapamil, ryanodine and low extracellular sodium) change significantly during the early phases of postnatal ontogeny . This development is obviously due to a disproportion between the rapidly increasing functional demands and the structural and functional ability of the myocardium to fulfil such requirements. These experimental data were obtained in healthy individuals; such an approach differs, however, from the clinical situation, where the pathogenic factors acting during the critical prenatal periods as well as soon after birth (eg, hypoxia, drugs) may have serious consequences for further maturation . It therefore seemed to be useful to follow the myocardial ontogenetic differences in animals exposed to prenatal and early postnatal intervention that may influence the functional properties of the developing heart.Infants of diabetic mothers were previously reported to be at risk for cardiovascular problems because of hypertrophic cardiomyopathy, and systolic and diastolic dysfunction, which may even progress to congestive heart failure during the neonatal period . These manifestations have been explained as a result of fetal hyperinsulinemia resulting from maternal hyperglycemia, and of myocardial enlargement induced by the growth stimulating effect of insulin. You can start online shopping right now – buy asthma inhalers for more advantages.

Category: Cardiology

Tags: Cardiac function, Experimental diabetes, Inotropic effect of calcium, Neonatal heart

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