Contractile parameters: The baseline absolute values of DF as well as the rate of contraction (+dF/dtmax) increased inboth groups during the whole investigated period; this increase was, however, significantly lower in the experimental group (Figure 1). Like the relative heart weight, DF normalized to heart weight in grams revealed two different phases: it decreased from birth to day 4 and increased significantly to day 7; there was no difference between the control and the experimental group.
Inotropic response to calcium: Inotropic response to increasing concentration of Ca2+ (expressed as DF/g heart weight) did not differ in one- and four-day-old hearts (with one exception: in offspring from diabetic mothers DF was significantly lower at a Ca2+ concentration of 1.25 mmol/L on day 4). On day 7, however, the DF of experimental hearts was significantly higher starting from a Ca2+ concentration of 1.25 mmol/L (Figure 2). You can finally spend less time to discover celexa for depression always paying lower prices.
Figure 1 Baseline absolute values of developed force (DF), rate of contraction (+dF/dtmax) and DF expressed per gram of heart weight in one-, four- and seven-day-old control (solid line) and experimental (dashed line) animals. *P<0.01
Figure 2 Inotropic response to increasing concentration of Ca2+ (expressed as DF per gram of heart weight) in one-, four- and seven-day-old control (solid line) and experimental (dashed line) animals. *P<0.01