Contractile parameters: The baseline absolute values of DF as well as the rate of contraction (+dF/dtmax) increased inboth groups during the whole investigated period; this increase was, however, significantly lower in the experimental group (Figure 1). Like the relative heart weight, DF normalized to heart weight in grams revealed two different phases: it decreased from birth to day 4 and increased significantly to day 7; there was no difference between the control and the experimental group.
Inotropic response to calcium: Inotropic response to increasing concentration of Ca2+ (expressed as DF/g heart weight) did not differ in one- and four-day-old hearts (with one exception: in offspring from diabetic mothers DF was significantly lower at a Ca2+ concentration of 1.25 mmol/L on day 4). On day 7, however, the DF of experimental hearts was significantly higher starting from a Ca2+ concentration of 1.25 mmol/L (Figure 2). You can finally spend less time to discover celexa for depression always paying lower prices.

Cardiac contractile function and inotropic responsiveness to calcium in newborn rats from diabetic mothers

Figure 1 Baseline absolute values of developed force (DF), rate of contraction (+dF/dtmax) and DF expressed per gram of heart weight in one-, four- and seven-day-old control (solid line) and experimental (dashed line) animals. *P<0.01

Cardiac contractile function and inotropic responsiveness to calcium in newborn rats from diabetic mothers

Figure 2 Inotropic response to increasing concentration of Ca2+ (expressed as DF per gram of heart weight) in one-, four- and seven-day-old control (solid line) and experimental (dashed line) animals. *P<0.01