Cardiac contractile function and inotropic responsiveness to calcium in newborn rats from diabetic mothers (part 7). DISCUSSION

rats from diabetic mothers (part 7). DISCUSSION

The inotropic response to increasing concentration of Ca2+ (expressed as percentage of the maximum value) did not vary in control hearts throughout the whole investigated period (Figure 3A). In experimental animals this parameter differed four-day-old hearts only: the curve was shifted to the right, indicating that the concentration at which 70% of the maximum DF was attained was significantly increased (Figure 3B). This suggests decreased sensitivity to extracellular Ca2+. A pharmacy deserving your trust and giving you zoloft antidepresant along with other services.

DISCUSSIONOur results show that body and heart weights of newborn rats from diabetic mothers were not different from those of control animals. On the other hand, sucklings of diabetic mothers suffered from severe growth retardation during the first week of life. It has been repeatedly described that the children of diabetic mothers tend to have higher amounts of body fat, total body weight and heart weight at birth than normal neonates of similar gestational age. These findings are consistent with the known anabolic action of insulin and led to the suggestion that the macrosomia in infants of diabetic mothers was due to excessive insulin secretion.

Cardiac contractile function and inotropic responsiveness to calcium in newborn rats from diabetic mothers

Figure 3 Inotropic response to increasing concentration of Ca2+ (expressed as percentage of the maximum value) on day 1 (solid line), day 4 (dashed line) and day 7 (dotted line) in control (A) and experimental (B) animals. *P<0.01 

Category: Cardiology

Tags: Cardiac function, Experimental diabetes, Inotropic effect of calcium, Neonatal heart

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