Cardiac contractile function and inotropic responsiveness to calcium in newborn rats from diabetic mothers (part 8)

rats from diabetic mothers (part 8)

Forthe explanation of this obvious discrepancy, species differences and the selected experimental model simulating the human disease have to be taken into consideration. Thus,it has been shown that fetal administration of streptozotocin decreases body weight of fetal rats . This model of diabetes represents a clinically manifested, mild, aketotic, untreated form of the carbohydrate metabolic disorder without any interference with insulin of the offspring. The impair-mentof some other functions, eg, lactation, cannot, however, be excluded. Growth retardation during the first week of life may, therefore, be the consequence of malnutrition and/or dehydration.Our results clearly indicate that the offspring of diabetic mothers exhibit changes in cardiac contractile function and inotropic responsiveness, particularly at the end of the first postnatal week: the baseline values of magnitude of contraction (expressed as DF/g heart weight) decreased, whereas the inotropic response to increasing concentration of Ca2+ (DF/g) was elevated in seven-day-old experimental animals. This implies that the experimental heart is significantly more dependent on extracellular sources of Ca2+, suggesting that the postnatal maturation of systems responsible for intracellular Ca2+ transients was delayed. It has been shown previously that some functional sarcoplasmic reticulum already exists in newborn rats. You will always come across zoloft generic offered by a reliable pharmacy.


Category: Cardiology

Tags: Cardiac function, Experimental diabetes, Inotropic effect of calcium, Neonatal heart

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