Archive for the ‘Anti-lnflammatory’ Category


anti-inflammatory drugs

The primary objective of this study was to examine ratings of helpfulness of analgesic and antiinflammatory medications among African-American and Caucasian veterans. To our knowledge, other observational studies of patients with OA have not directly examined patients’ perceptions of helpfulness of specific, current medications. In clinical trials, pre-and post-treatment scores on standardized pain scales are the usual primary outcome. Assessment of patients’ perceptions of medication helpfulness is a clinically useful alternative measure that may have implications for adherence and continuation of use.

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The study sample included 141 African-American and 61 Caucasian veterans with OA. Demographic and clinical characteristics according to race are presented in Table 1. The sample was predominantly male (91%), which is characteristic of VA healthcare users, and about half had some college education. African-American patients were significantly younger than Caucasian patients, had a smaller proportion of males, and had greater disease severity.

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Sample

Participants were patients of the Durham VA Medical Center who completed an in-person survey between March 2002 and January 2003. Potential participants were initially identified on the basis of an ICD-9 code indicating OA (715), using VA electronic medical records. We also identified individuals with an upcoming clinic appointment, so that the in-person survey could be conducted in conjunction with a regularly scheduled clinic visit. This was done because many VA patients travel long distances for their clinic appointments. Patients were recruited by telephone. Among 359 veterans who were contacted, 32 indicated they did not have OA, and 29 stated their upcoming VA appointment had been cancelled or rescheduled. Of the remaining 298 eligible patients, 25 refused participation. Another 68 individuals initially agreed to participate but then did not show up for the interview. This is likely due to skipping or rescheduling clinic appointments. An additional three veterans did not provide self-reported race on the survey. Since the current analyses focus on racial differences, they were also excluded. The final sample for these analyses included 202 African-American and Caucasian veterans.

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analgesics

INTRODUCTION

Osteoarthritis (OA) affects 21 million individuals in the United States and is a leading cause of disability among older adults. In the next two decades, our nation’s healthcare systems will face the challenge of treating a rapidly increasing number of older adults, including a growing population of ethnic minorities, with OA. Pharmacotherapy is the cornerstone of treatment for OA. Yet little is known about how patient demographic and clinical characteristics are related to perceived efficacy of analgesic and anti-inflammatory medications. It is particularly important to examine the relationship of race to pain medication efficacy, since there are known racial differences in pain thresholds, sensitivity, and perceptions.

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