Archive for the ‘Diabetes’ Category

6 myths about diabetes

Oct 11, 2012 Author: Walter Mcneil | Filed under: Diabetes


Unreliable information about something is frequently a bad friend. In this post I would like to explode some of the silliest myths about diabetes that are scary and silly at the same time. So, here they are:
Myth #1. Diabetes is an easy-to-catch infection.
It is not true. The lack of insulin that results in increased blood sugar level (and, correspondently, diabetes) occurs due to genetic predisposition, malnutrition and some other factors. There is no shadow of infection. More than that insulin-independent, or type 2 diabetes, may occur as a result of constant overeating and the excess of easy digestible carbohydrates (oversweet tea, rolls, baked confections, etc.). They buy diabetic drugs to keep the glucose level under control.
Myth #2. People, diagnosed with diabetes mellitus, should exclude from ratio potatoes, macaroni and baked foods, because they are rich in starch. (more…)

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  • Two Cases of Monckeberg’s Medial Sclerosis on the Face: DISCUSSION

    Jan 19, 2011 Author: Walter Mcneil | Filed under: Diabetes

    Calcification in the media of peripheral arteries is defined as Monckeberg’s medial sclerosis and can be seen in diabetic and elderly individuals. The calcium salt is usually deposited between muscle cells in the media. Although its etiology is still not known, its presence can predict the risk of cardiovascular events and leg amputation in diabetic patients. There have also been a few cases where healthy young men have had the medial calcification.

    Generally, there are thought to be two different forms of arterial calcification: One is arterial intimal calcification, or atherosclerosis, and the other is medial calcification. Intimal calcification shows large and discontinuous calcific deposits in large and medium-sized arteries and a higher level of calcific deposit can lead to intraluminal stenosis or partial obstruction. However, medial calcification can be more finely grained and tends to involve the entire circumference or peripheral of small to medium-sized arterioles diffusely, so rather than obstruct the vascular lumen, it supports the structure.


    Two Cases of Monckeberg’s Medial Sclerosis on the Face: Case

    Jan 18, 2011 Author: Walter Mcneil | Filed under: Diabetes

    Case 1

    A 60-year-old man presented with a 3-year history of a solitary, bean-sized pulsatile nodule on his left nasolabial fold (Fig. 1A). He had basal cell carcinoma on the left side of the nasal ala which had been removed by an excisional operation in 2002. While excising the lesion, a pulsatile nodule had been found on the left nasolabial fold. It had been removed together with the basal cell carcinoma, and histopathologically was to be Monckeberg’s medial sclerosis. He had no history of other diseases such as diabetes mellitus or hyperten­sion and there were no abnormal results from the laboratory tests or physical examination. During the operation, the pusatile nodule turned out to be an inferior labial artery from the facial artery, and changed into a convoluted waxy-walled vessel (Fig. 1B). The surgeons cut both ends of the calcified lesion, and ligated each end of the vessel. The excised artery biopsy showed some discontinuous calcification on the media of the vessel (Fig. ЗА). A von Kosa stain showed medial calcification more clearly (Fig. 3B). We report that two years on from the operation, no sign of recurrence on the excised portion has been observed.


    Two Cases of Monckeberg’s Medial Sclerosis on the Face

    Jan 17, 2011 Author: Walter Mcneil | Filed under: Diabetes

    Diabetes mellitus


    Monckeberg’s medial sclerosis, known as a medial calcification of the arteries, is an age-related degen­erative process especially caused by long-standing diabetes mellitus. The vessels most commonly affected are large and medium sized peripheral muscular arteries such as femoral, tibial, radial, ulnar, and uterine arteries. Affected vessels, which get dilated hard when palpated, histopathologically show transverse ridges of medial calcification under the intima. Since medial calcification of arteries was first described in the elderlj, and more frequently in diabetic patients in 1924 , many cases of medial calcification on the labial, temporal, mammary, coronary and facial arteries have been reported in foreign countries. However, there has been no case reported in the Korean dermatologic literature. (more…)

    TYPE-2 DIABETESIn population pharmacokinetic analyses from three large clinical trials, including 642 men and 405 women with type-2 diabetes (35 to 80 years of age), the pharmacokinetic properties of rosiglitazone tablet were not influenced by age, race, smoking, or alcohol consumption. Both oral clearance (CL/F) and the oral steady-state volume of distribution (Vss/F) rose with increases in body weight. Over the weight range observed in these analyses (50 to 150 kg), the range of predicted CL/F varied by less than 1.7-fold; that of Vss/F varied by less than 2.3-fold. Rosiglitazone’s CL/F was also influenced by both weight and sex, being lower by approximately 15% in women.


    Management of Diabetes: IMPACT MODEL REPORT

    Apr 24, 2010 Author: Walter Mcneil | Filed under: Diabetes


    Even though TZDs have been tested experimentally for other insulin-resistant conditions (e.g., non-alcoholic fatty liver disease, polycystic ovary syndrome, and lipodystrophies), these agents are indicated only for the treatment of type-2 diabetes at this time.


    Management of Diabetes: PHARMACODYNAMICS

    Apr 23, 2010 Author: Walter Mcneil | Filed under: Diabetes

    In patients with type-2 diabetes, the decreased insulin resistance produced by generic pioglitazone results in lower values of blood glucose, plasma insulin, and glycosylated hemoglobin (HbA1c). Based on results from an open-label extension study, the glucose-lowering effects of pioglitazone appeared to persist for at least one year. In controlled clinical trials, pioglita-zone, in combination with sulfonylurea, metformin, or insulin, had an additive effect on glycemic control. Patients with lipid abnormalities were included in clinical trials of pioglitazone.


    Management of Diabetes: PHARMACOKINETICS

    Apr 22, 2010 Author: Walter Mcneil | Filed under: Diabetes


    Both rosiglitazone and generic pioglitazone are well absorbed with excellent bioavailability. The absolute bioavailability of rosiglitazone is 99%. Peak plasma concentrations of rosiglitazone are observed about one hour after dosing, whereas pioglitazone is first measurable in serum within 30 minutes, with peak concentrations observed within two hours. Administration of both agents with food results in no clinically significant pharmaco-kinetic alterations.




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