Prior studies have established that patients with inflammatory bowel disease, especially those with extensive and long-standing ulcerative colitis, have an increased risk of subsequent colorectal cancer. These studies of ulcerative colitis, however, have been based on data from tertiary care settings, primarily in the United States and the United Kingdom. Others practising in similar geographic areas, particularly in the United States, have shown that the magnitude of risk may not be significant, while some have argued that the risk of cancer is not increased in patients with colitis. A number of studies have also suggested that patients with Crohn’s disease have an increased risk of colorectal cancer. In Canada, some have assumed that the risk of cancer in patients with ulcerative colitis or Crohn’s disease is similar to that observed in American centres, but, to date, there have been no published studies from Canada. Your drugs could cost you less – buy serevent inhaler to start the treatment soon.
The present report describes an experience with colorectal cancer using a single clinician database, developed during a 20-year period, in 877 patients with Crohn’s disease in a tertiary care teaching hospital setting. The results of this study indicate that colorectal cancer may complicate the clinical course of Crohn’s disease, particularly in younger men with long-standing disease, but part of this increased risk may be due to possible factors associated with the presence of a residual rectal stump rather than to Crohn’s disease per se.