Hemangioma

INTRODUCTION

Mast cells are specialized secretory cells distri­buted in connective tissues throughout the body. In the skin, mast cells are present in the papillary dermis, near the dermo-epidermal junction, in the sheath of epidermal appendages, and around the blood vessels and nerves of the subpapillary plexus. Mast cells synthesize various kinds of mediators, some of which are preformed and stored in the granules, while others are synthesized and released without storage. Among the mediators of mast cells, heparin, tumor necrosis factor a (TNF-a), transforming growth factor в (TGF- в), basic fibro­blast growth factor (bFGF), tryptase, vascular permeability factor (VPF), and vascular endothelial growth factor (VEGF) have been suggested to contribute to various aspects of neovascularization. In addition, some reports have shown the increased number of mast cells and angiogenic mediators from mast cells are increased in hemangiomas and vascular malformations. However, the simultaneous occurrence of mastocytoma and hemangioma is rarely reported. We describe a case of combined mastocytoma-hemangioma that occurred in a pa­tient with urticaria pigmentosa. Viagra Professional