A further way to characterize the differences between the first- and second-generation sulphonylureas is their affinity for membrane channels. Sturgess et al demonstrated the pancreatic sulphonylurea receptor as an ATP-sensitive potassium channel. The affinity of different sulphonylurea compounds to ATP-sensitive potassium channels varies in relation to their hypoglycemic efficacies . Considering that many organs also have ATP-sensitive potassium channels, the sulphonylurea drugs might have direct or indirect cardiac, neurogenic or hormonal actions. Fosset et aldemonstrated a higher affinity of second-generation sulphonylurea  to receptors linked to ATP-dependent potassium channels in myocytes, compared with the first-generation agents. Nevertheless, until now there has been no evidence for any opposite action of first- and second-generation sulphonylurea compounds on extrapancreatic ATP-sensitive potassium channels, which may explain their opposite in vivo effects on arrhythmogeneity.
Data in the present study demonstrate that second-generation sulphonylurea compounds potentiate the arterial blood pressure depression induced by vagal stimulation. As far as the heart rate response is concerned, only glibencla-mide stimulated the bradycardiac effect of parasympathethic stimulation. It is known that sudden cardiorespiratory arrest and unexpected deaths have been observed in patients with diabetes mellitus complicated by autonomic neuropathy. There is always a great pharmacy waiting for you to visit and purchase the amount of medicine you need, be that or any other one. You can see that all for yourself once you visit, enjoying most advantageous deals ever.