Effect of hypoglycemic sulphonylureas on vagal functions: DISCUSSION (part 3)

DISCUSSION (part 3)The neuropathic cases with prolonged QT interval are also often associated with malignant ventricular arrhythmias.  Therefore, the above data seem to be very important. Glibenclamide improves cardiac innervation by acting through the central nervous system, thus on the one hand contributing to its direct antiarrhythmic effect, and on the other hand positively influencing and possibly counteracting the manifestations of cardiac autonomic neuropathy. Although the other second-generation sulphonylurea compounds stimulate only blood pressure depression due to vagal stimulation, this influence could also contribute to their advantageous cardiac effects.
On the basis of the results presented here, it can be concluded that the various sulphonylurea drugs may affect the autonomic nervous function of the heart differently, resulting sometimes in opposite cardiac activity. Buy best quality medications online at the pharmacy that will make sure your are happy with the prices and the quality of your whenever you need some treatment and have no idea where to get it.

Effect of hypoglycemic sulphonylureas on vagal functions

Figure 2 Effects of sulphonylureas on percentage alterations in arterial blood pressure induced by electrical stimulation of the vagal nerve in dogs. The effect of stimulation with increasing frequency on the blood pressure is projected in the frontal plane, while that of the selected doses of sulphonylureas is projected in the lateral plane, resulting in the stereoscopic illustration. Differences (mean ± SEM) are compared with solvent 



Category: Cardiology

Tags: Arterial blood pressure, Heart rate, Hypoglycemic sulphonylureas, Vagal stimulation

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