A MEDLINE literature search was performed (for the period 1966-2002) to identify randomized, placebo- controlled trials and meta-analyses examining the use of the antidepressants bupropion and nortriptyline for smoking cessation. The search terms were “smoking cessation”, “abstinence”, “bupropion”, and “nortriptyline.” Only studies with a follow-up duration of at least 6 months were included. Studies that described smoking cessation in patients with primary mental illness were excluded. Trials were also excluded if they dealt with relapse or if the primary objective was to identify predictors of response to oral therapy. In addition, a recent Cochrane review of antidepressants was examined.
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