Pulmonary and Aortic Blood Flow Measurements in Normal Subjects and Patients After Single Lung Transplantation: Conclusion

In addition, areas of SLTX arteries were larger than those of the native pulmonary arteries, both in peak systole and end diastole. Thus, increased flow to the LTX compared with the native lung is accompanied by both higher flow velocities and larger vessel area, but without changes in DI.
One drawback of our study might be the fact that volunteers differed from patients with regard to gender and age distribution. However, Davidson and Fee have shown that there are no differences in pulmonary hemodynamics and cardiac output between men and women. In the same study, the authors nevertheless found an increase of pulmonary artery pressure and resistance with aging. Still, these differences were only significant when comparing a population >60 years with much younger individuals and the overall values were within the normal range. In that respect, differences in mean ages between volunteers and patients (27.7±6.7 years vs 43.7± 13.3 years) might be only of minor significance. The fact that the time interval between transplantation and MRI examination ranged from 30 days to 18 months is another potential drawback of this study. Buy claritin online comments However, there was no chance to perform repeat MRI measurements for follow-up in these patients. Also, a statistical comparison between MRI data obtained early and at a more later time after surgery seems not to be warranted because of the small patient population.
In conclusion, noninvasive measurements of main and differential pulmonary flow and velocity by VEC-MRI in SLTX patients provide understanding of the pathophysiologic changes of the pulmonary arterial system after SLTX. Accurate assessment of differential pulmonary blood flow to the transplanted and native lungs can be obtained and the RI might reflect PVR. The DI does not provide relevant information. The value of VEC-MRI to assess various posttransplant disorders, such as rejection or stenosis at the site of the pulmonary anastomosis, must be established based on findings in SLTX patients with an unremarkable postoperative course.

Category: Lung Transplantation

Tags: lung transplantation, magnetic resonance flow measurements, pulmonary hemodynamics