Quality of Life in Patients With Lung Cancer: Radiotherapy

Quality of Life in Patients With Lung Cancer: RadiotherapyAlthough these findings are not consistent, the results suggest that when there is no clinical benefit, for example in survival time or tumor response, perceptions and attitudes of patients toward different treatment policies could provide additional information. Therefore, measuring quality of life becomes essential, and it seems that it is the most reasonable way of judging the clinical outcomes. As Hopwood and Cull remind us, there is no guarantee that adding quality of life measures makes the choice of treatment policy easier, but it does serve to clarify the potential trade-offs that need to be discussed with patients. There is evidence that physical functioning, treatment side effects, disease-related symptoms, psychological distress, fatigue, and malaise are the most relevant aspect of quality of life in patients receiving chemotherapy. Furthermore, fatigue and malaise were found to be global indicators of quality of life. Using such findings may provide a better understanding of clinical achievements. It is argued that it is important to ascertain what patients feel about the trade-offs between improved quality of life and toxicity where there is a significant potential for long-term side effects that may result in less than an optimum quality of life. cialis professional

Radiotherapy
Little is known about the effect of radiotherapy on a patient’s quality of life. The International Association for the Study of Lung Cancer workshop on quality of life reported that local radiation in addition to chemotherapy in small cell lung cancer showed a significant advantage in median and long-term survival. Randomized trials of prophylactic cranial irradiation (PCI) have failed to demonstrate survival advantage. Recent meta-analysis of thoracic radiotherapy for small cell lung cancer has also confirmed the view that radiotherapy can have survival benefits.
Studying 53 patients receiving therapeutic or elective brain irradiation, it was found that patients receiving elective irradiation had both better survival and quality of life as measured by the KPS. The role of chemotherapy in addition to radiotherapy has been studied, and it was shown that patients receiving immediate chemotherapy plus radiotherapy had better survival, as compared to groups of patients who received palliative treatment. In terms of quality of life, physicians reported a better “condition” in favor of immediate chemotherapy plus radiotherapy, but patients reported a better quality of life in favor of palliative treatment. Both groups reported the same “overall condition” and anxiety. Recently Cull et al have reported the results of a retrospective study on 52 patients who had received PCI. They observed that anxiety and depression in these patients were lower than patients recently receiving active treatment. However, it was found that a high proportion of patients still experienced treatment-related symptoms, but not functional impairment.
These studies highlight the palliative effect of the radiotherapy in the management of small cell lung cancer. Radiotherapy is a common treatment, but there are few studies that investigate the quality of life in patients receiving radiation treatment. The need to conduct such studies is essential.

Category: Cancer

Tags: chemotherapy, lung cancer, non-small cell lung