Simultaneous blockade of the cyclooxygenase and L-arginine-nitric oxide pathways prevents the antiarrhythmic effects of classical preconditioning (part 1)

classical preconditioning (part 1)It is well established that short periods of sublethal ischemic episodes protect the myocardium against the serious consequences of a subsequent prolonged ischemia-reperfusion insult. This form of cardiac adaptation is known as ischemic preconditioning , and is manifested by a delay in myocardial ischemic damage and cell necrosis , by enhanced recovery of contractile function during reperfusion , and perhaps, most important, by a marked reduction in ischemia and reperfusion-induced ventricular arrhythmias .Although the precise mechanisms of this antiarrhyth mic protection afforded by preconditioning are unclear, we have put forward the hypothesis (reviewed in 6-9) that the brief ischemic insults involved in preconditioning result in the release of ‘endogenous myocardial protective substances’ . These substances, through binding and stimulation of relevant receptors, initiate intracellular signal transduction mechanisms that ultimately lead to the protection of the myocardium.

There is some evidence that the marked antiarrhythmic effects of preconditioning involve the generation of nitric oxide and bradykinin . Bradykinin is perhaps the initial trigger for nitric oxide release from endothelial cells and from cardiac myocytes , and for the release of a cardioprotective prostanoid, probably prostacyclin. You can get all the drugs you want for treating your problem in no time if you order it at the my canadian We are recommending this pharmacy with confidence because it already has thousands of satisfied customers.

Category: Cardiology

Tags: Cyclooxygenase pathway, Ischemic preconditioning, L-arginine-nitric oxide pathway

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