In control dogs subjected to a 25 min occlusion, 42% of the dogs fibrillated during occlusion and all dogs died following reperfusion. In contrast, in preconditioned dogs, none died during the 25 min occlusion and 50% of the dogs survived reperfusion. In the two dogs in which L-NAME and meclofenamate were given before preconditioning (group 4) one dog died (VF) during occlusion and the other during reperfusion. Thus, no dog in this group survived.
When dogs were given meclofenamate and L-NAME after the preconditioning procedure, but before the prolonged occlusion (group 3), one of the six dogs (17%) died during occlusion and four dogs fibrillated on reperfusion. Thus, survival in this group was 10%.Changes induced by inhibition of the L-arginine-nitric oxide and cyclooxygenase pathways in the degree of inhomogeneity of activation within the ischemic area and in the epicardial electrocardiogram: As shown previously, the inhomogeneous conduction that occurs within an area of the LV wall supplied by the occluded coronary artery is markedly reduced by preconditioning. Inhomogeneity of electrical activation was still largely suppressed when L-NAME and meclofenamate were given after the preconditioning procedure, but was markedly increased when both were administered before the preconditioning protocol (Figure 6). Find out more about your chance to visit the most trusted pharmacy you could ever find to get flovent for asthma in the amounts required, without any need to see your health care provider first or get a prescription.
Figure 6 Degree of inhomogeneity of electrical activation within the ischemic area during a 25 min coronary artery occlusion in control dogs (open circles), in preconditioned (PC) dogs (closed circles), in dogs that were PC but then given a combination ofsodium meclofe-namate (MF) and NG-nitro-L-arginine methyl ester (L-NAME) (closed triangles) and in dogs given both inhibitors before PC (open triangles)