Simultaneous blockade of the cyclooxygenase and L-arginine-nitric oxide pathways prevents the antiarrhythmic effects of classical preconditioning (part 11)

Occlusion of a coronary artery also results in a rapidly developing elevation of the epicardial ST segment. This is most marked when the coronary artery is occluded for the first time, ie, during the first preconditioning occlusion (groups 2 and 4) or during the first 5 to 10 mins of the prolonged occlusion (control group). The second preconditioning occlusion and the prolonged occlusion in preconditioned dogs results in slower development of ST segment elevation and is less marked (Figure 7).However, in dogs in which meclofena-mate and L-NAME were given before preconditioning, the increase in epicardial ST segment was significantly greater, during both the two preconditioning occlusions (there was now no difference between them) and the prolonged occlusion. In dogs in which the blockade was performed after the preconditioning procedure, the elevation in the epicardial ST segment, during both preconditioning and prolonged occlusion, was similar to that in the preconditioned dogs. You have a great opportunity to discover the pharmacy that will always be sure to live up to your highest expectations, no matter if you would like to get cheap asthma medications or buy any other prescription medicine with no prescription required on very advantageous terms.

Simultaneous blockade of the cyclooxygenase and L-arginine-nitric oxide pathways prevents the antiarrhythmic effects of classical preconditioning

Figure 7 Changes in epicardial ST segment elevation during two preconditioning (PC) occlusions (with a 20 min reperfusion period in between) and, 20mins later, a 25 min occlusion of the same artery. Control data are represented by open circles (prolonged occlusion only), PC dogs by closed circles, PC dogs in the presence of a combination of meclofenamate (MF) and NG-nitro-L-arginine methyl ester (L-NAME) by open triangles andPC dogs subsequently given a combination of MF and L-NAME before the prolonged occlusion by solid triangles. PC markedly reduced ST segment elevation during the prolonged occlusion, and this was unaffected if dual blockade was carried out before that occlusion. In contrast, dual blockade before PC (open triangles) intensified ischemia during both PC occlusions and the prolonged occlusion. *P<0.05 

 

Category: Cardiology

Tags: Cyclooxygenase pathway, Ischemic preconditioning, L-arginine-nitric oxide pathway

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