Hemodynamic effects of meclofenamate, L-NAME and coronary artery occlusion: The hemodynamic effects of meclofenamate and L-NAME are summarized in Table 1. Meclofenamate administration resulted in no sufficient changes in any hemodynamic parameter. However, infusion of L-NAME significantly increased arterial blood pressure and LV systolic pressure, and reduced heart rate, LV end-diastolic pressure, and both positive and negative LV dP/dt (Table 1). Following coronary artery occlusion, changes in diastolic and mean arterial blood pressures were somewhat more marked after this drug treatment. Reductions in positive and negative LV dP/dt were similar in both groups.
The protocol was as follows (Figure 1).
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Figure 1 Experimental protocol for studies designed to evaluate the respective roles of nitric oxide and prostanoids in protection against ventricular arrhythmias by ischemic preconditioning (PC). PC was induced by two 5 min coronary artery occlusions separated by a 20 min reperfusion period; the control occlusion, 25 mins in duration, was begun 20 mins after the end ofthe second PC occlusion or afterPC but before the prolonged ischemic period. ic Intracoronary injection; iv Intravenous injection; L-NAME NG-nitro-L-arginine methyl ester; MF Meclofenamate
TABLE 1 Hemodynamic effects of meclofenamate (2 mg/kg intravenously) and L-NAME (5 mg/kg intracoronary injection)
|Arterial blood pressure (mmHg)|
|LV systolic pressure (mmHg)||125±7||130±7||5±2||129±7||147±4||18±3*|
|Heart rate (beats/min)||151±9||01±35
|LV dP/dtmax (mmHg/s)|
*P<0.05; n = 19. LV Left ventricle; L-NAME