The confidence of physicians and patients in treatment decisions about theophylline use did not differ, whether the decision was based on an n of 1 trial or on standard practice (median confidence level in decision for physicians,  [range, 1 to 4]; median confidence level in decision for patients, 2 [range, 1 to 6]). The confidence level of physicians was slightly higher following the n of 1 trial (median, 2; range, 1 to 4) than following standard practice (median, 3; range, 1 to 4). The confidence level of patients also was higher following the n of 1 trial (median, 2; range, 1 to 6) than following standard practice (median, 2.5; range, 1 to 6). However, these differences were not significant.
Comparison of n of 1 Trial and Standard Practice Patients According to Duration of Theophylline Use at Entry (Secondary Analysis)
Tables 2 and 3 also show the CRQ scores, 6-min walk results, and results of theophylline therapy over time among n of 1 trial patients and standard practice patients according to the prerandomization strata. An apparent interaction was present between previous theophylline use and theophylline treatment groups in the CRQ Emotional Function scores at 6 months (p = 0.034) and 12 months (p = 0.039). Comparisons between n of 1 trial patients and standard practice patients within the subgroups at 6 and 12 months were not significant, with the exception of an increase in the Emotional Function score among n of 1 trial patients ( + 5.6) compared with a decrease among standard practice patients (-2.2) at 6 months (p = 0.013, unpaired t test) within the no-prior-theophylline-use group buy allegra online buy allegra online.
The mean baseline theophylline level was higher in the prior-theophylline-use group than in the no-prior-theophylline-use groups (64mol/L vs 49 mol/L, respectively; p = 0.002). A greater number of prior-theophylline-use patients than no-prior-the-ophylline-use patients were taking theophylline at 12 months (22/35 patients [63%] vs 9/26 patients [35%], respectively; p = 0.02). Among no-prior-theophyl-line-use patients, no differences were seen in the proportion of n of 1 trial patients and standard practice patients taking theophylline over time. Among prior-theophylline-use patients, more standard practice patients than n of 1 trial patients were taking theophylline at 3 months (26% more) and 6 months (21% more). However, these differences were not statistically significant (3 months, p = 0.18; 6 months, p = 0.19; Fisher’s exact test).