nasal positive pressure

Mechanically-assisted positive pressure ventilation can effectively provide ventilatory support in acute and chronic respiratory failure, but typically requires the placement of an artificial airway, with its associated complications. Alternatively, intermittent negative pressure ventilation applied noninvasively has been shown to be useful in the treatment of chronic respiratory failure resulting from neuromus­cular and chest wall disorders, as well as chronic obstructive pulmonary disease. The sustained im­provements in ventilatory function which have been observed have generally been attributed to resting of chronically fatigued inspiratory muscles.

Recent descriptions of positive pressure ventilation applied through a tightly fitted nasal mask (NPPV) suggest that NPPV is an alternative noninvasive method of providing intermittent ventilation with ease of application and good patient acceptance. Long- term use of NPPV has resulted in improvement in clinical status and in parameters of ventilatory function between treatments. In order to investigate the possible mechanism responsible for these beneficial effects, we evaluated the ability of NPPV to decrease spontaneous inspiratory efforts in normal subjects and in patients with acute or chronic respiratory failure of varied etiology. levitra plus